Numerous studies have connected innate immunity and neuroinflammation to the AD pathogenesis (Glass et al., 2010; Eldik et al., 2016; Kinney et al., 2018) and the first AD gene involved in innate immunity, CD33, was discovered in family-based associations study in 2008 (Bertram et al., 2008) followed by many more innate immune genes (Bertram and Tanzi, 2019). The gene discussed is CD33; the disease is Alzheimer disease.