SHR model can be associated with various central nervous system (CNS) indications such as KCNQ2-related epileptic encephalopathy (Berg, 2016) or various orphan forms of epilepsy (Russo et al., 2017; Berg, 2018; Becari et al., 2020), however, it is extensively used as the gold standard rodent model of ADHD. The gene discussed is KCNQ2; the disease is attention deficit-hyperactivity disorder.