BRCA1 and breast cancer: The leading risk factors for BC include age, genetic mutations (BRCA1 and BRCA2) (7), lifestyle-based (non-genetic) risk factors (8), early menarche, nulliparity, first pregnancy after the age of 30 years, older age at menopause, dense breast tissue (9), hormone replacement therapy (10), use of oral contraceptives (11), personal and family history of BC, and other clinical complaints (12, 13).