There is a downregulation of CXCR3 on NK cells, along with an upregulation of CXCL9, CXCL10 and downregulation of CXCL12, along with a general dysregulation of the CXCR4/CXCL12 axis in the MM microenvironment. This evidence concerns the gene CXCR4 and Miyoshi myopathy.