As shown in Table 3, in T2DM patients, serum VEGF-B level was positively correlated with triglyceride (r=0.172, p=0.013), serum creatinine (r=0.150, p=0.031) and cystatin C (r=0.245, p<0.001) while inversely correlated with HDL-C (r=-0.138, p=0.047) and eGFR (r=-0.205, p=0.003) after adjusting gender, age, smoking history, drinking history, diabetes duration and BMI. This evidence concerns the gene CST3 and type 2 diabetes mellitus.