Interestingly, no significant correlation between serum VEGF-B and UTP nor UACR was observed, which suggested that the relationship between serum VEGF-B level and renal function impairment in T2DM patients was independent of albuminuria, and the VEGF-B up regulation is likely to be a new mechanism underlying NADKD in T2DM patients. The gene discussed is VEGFB; the disease is type 2 diabetes mellitus.