The Cardiovascular Health Study of 5417 individuals aged 65 years or older without previous stroke, after 10.2 years of follow-up, found that the adjusted HR in the 4th quartile of CRP level was 1.60 (95% CI: 1.23–2.08) for ischemic stroke relative to the 1st quartile [16]. The gene discussed is CRP; the disease is ischemic stroke.