GNRH1 and osteoporosis: In addition, other signaling pathways, such as inflammatory mediator regulation of TRP channels (hsa04750) [39], neuroactive ligand-receptor interaction (hsa04080) [40], signaling pathway (hsa03320) [41], and GnRH signaling pathway (hsa04912) [42], are also involved in the regulation of bone metabolism and the pathogenesis of osteoporosis.