HIV interferes with the production of hepatic coagulation factors in the liver increasing factor VIII, fibrinogen and plasminogen activator inhibitor 1 (PAI1), and reducing antithrombin and protein C levels.12,30,31 The causal relationship between TB and VTE is also demonstrated in the improved pro-thrombotic state a month after initiating TB therapy and the introduction of rifampicin that induces the hepatic coagulation protein synthesis and increases the risk of thrombosis.31,32. This evidence concerns the gene SERPINE1 and tuberculosis.