CCT3 played a critical role in gastric cancer growth and survival 13, Peng Su et al. displayed that CCT2-CCT7 are upregulated in esophageal carcinoma 24, Shi et al. showed the significant upregulation of CCT3 in PTC samples and that CCT3 knockdown decreases cellular proliferation and cell cycle progression and induces apoptosis in K1 cellspapillary thyroid carcinoma 26, Xiong Y et al. concluded that some genes, including CCT3, COPS3 and WWP1 are candidate driver genes of importance in osteosarcoma (OS) tumorigenesis PPI network analysis 27. This evidence concerns the gene CCT3 and osteosarcoma.