Immunohistochemical staining intensity and range-based scoring revealed that the mean immunohistochemical scores of SPARC (P < 0.05, Figure 2B), VEGF (P < 0.05, Figure 2D), PDGF (P < 0.05, Figure 2F), and TGF-β (P < 0.05, Figure 2H) were significantly higher in the CRC tissue than in the adjacent normal tissues. This evidence concerns the gene SPARC and colorectal carcinoma.