Acetyl-CoA can be hydrolyzed by acyl-CoA thioesterase 12 (ACOT12)12, and the other enzymes responsible for regulation of acetyl-CoA, including adenosine triphosphate (ATP)-citrate lyase (ACLY), acetyl-CoA synthetase 1 (ACSS1), acetyl-CoA synthetase 2 (ACSS2), pyruvate dehydrogenase complex (PDC) and acyl-CoA carboxylase1 (ACC1), are reported to participate in tumor growth and progression13-17. Here, ACSS2 is linked to neoplasm.