NOS2 and neoplasm: We found significantly increased expression of Ifnγ (p=0.0294) and Nos2 (p=0.0429) genes associated with M1 TAMs, and significantly decreased expression of CD206 (p=0.0329) and Ym1 (p=0.0391) genes associated with M2 TAMs after ONP-302 treatment (Figure 3B). Additionally, expression of Mmp9 encoding for an ECM remodeling protease implicated in tumor progression and metastasis also was decreased significantly (p=0.0279) (Figure 3B).