CASP3 and neoplasm: As shown in Fig 6B, tumor tissues obtained from pcTERT-Noxa or pcTERT-Puma groups showed a substantial increase in the expression of cleaved PARP1, cleaved Caspase-9, cleaved Caspase-3 and Bax in tumor, which was similar to the in vitro results as shown in Fig 4A. However, Bcl-2 expression indicated that there was no obvious variation in pcTERT-Noxa group or pcTERT-Puma group as compared to pcTERT injection group.