CASP3 and neoplasm: Moreover, mitochondrial related proteins Bax, cleaved Caspase-3, cleaved Caspase-9, and cleaved PARP1 levels were stimulated after pcTERT-Noxa or pcTERT-Puma injection in the tumor tissues in vivo, which was consistent with the in vitro results as described above and have also addressed some limitations associated with our previous study 26.