Consistently, matrigel invasion experiment by using transwell assay indicated the ability of tumor cells to undergo invasion, which represented that the percentage of stained HepG2 cells that had significantly penetrated into the transwells were substantially reduced in pcTERT-Noxa (0.162±0.003) or pcTERT-Puma (0.160±0.003) groups, as compared with pcTERT (0.240±0.012) (Fig 3C). The gene discussed is BBC3; the disease is neoplasm.