It showed that SLC7A11 was up-regulated in patients or mice with lung adenocarcinoma (Fig. 4A-B) We detected the correlation between the expression of miR-339 and SLC7A11 from the perspective of mRNA and protein, and found that miR-339 negatively regulates the expression of SLC7A11 (Fig. 4C-E, Fig. S2A-B). This evidence concerns the gene SLC7A11 and lung adenocarcinoma.