Mechanistically, simvastatin reduces the cholesterol level of the cell membrane, which destroys the integrity of lipid rafts, promotes Fas translocation into lipid raft fractions, leads to downregulation of the PI3K/Akt signaling pathway, and results in caspase-3-dependent apoptosis of GBM in vitro 66. This evidence concerns the gene CASP3 and glioblastoma.