DNM1L and Hyperglycemia: In accordance with the results from endothelial cells in high glucose, reinstitution of good glycemic control after a period of poor glycemic control in rats failed to ameliorate the hyperglycemia-induced increase in Drp1 mRNA in the retinal vasculature, and the GTPase activity of Drp1 also remained high; values obtained from rats in PC and PC-GC groups were not different from each other (p > 0.05), but were significantly higher than those in norm group (p < 0.05; Figures 7(a) and 7(b)).