However, when related events such as hypertension and hyperglycemia occur, endothelial cells activate and consequently express monocyte chemoattractant protein-1, interleukin (IL)-8, intercellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), E-selectin, P-selectin, and other inflammatory factors, resulting in monocyte retention and triggering chronic inflammatory injury (80). Here, ICAM1 is linked to Hyperglycemia.