Kaler P et al. confirmed that IL-1β can induce Wnt signaling and tumor cell growth by the inactivation of GSK3β [26], thereby causing the immune escape in patients with colon cancer, which was also indirectly confirmed by the negative correlation between immune cell infiltration fraction and the risk score in our present study (the low-risk group has a higher neutrophil immune infiltration rate than the high-risk group). This evidence concerns the gene GSK3B and malignant colon neoplasm.