TRPS1 and cancer: In the present study, we performed microarray expression profile analysis in paclitaxel-resistant MDA-MB-231 cells and identified an orphan lncRNA, AF178030.2, which was extensively upregulated in paclitaxel-resistant cells and was able to mediate the sensitivity and resistance to paclitaxel by downregulating the expression of trichorhinophalangeal syndrome-1 (TRPS1), an important regulator in epithelial-mesenchymal transition, which was found to be one of the main reasons to induce drug resistance in many cancers.