INS and Hyperglycemia: Wang et al. [40] significantly improved glucose homeostasis and observed markers of new β-cell formation (insulin, PDX1, and Ngn3) in the pancreatic ducts of high-fat diet-induced diabetic mice treated with Puerarin, suggesting that Puerarin can promote β-cell regeneration through GLP-1R signal activation and improve hyperglycemia in HFD diabetic mice.