AKT1 and alcohol dependence: As shown in Figure 4(d), KEGG pathway enrichment analysis suggested that the targets were mainly related to signaling pathways, such as systemic lupus erythematosus, alcoholism, viral carcinogenesis, cell cycle, prostate cancer, transcriptional misregulation in cancer, the thyroid hormone signaling pathway, hepatitis B, the PI3K-Akt signaling pathway, and pathways in cancer.