One recent study reported that miR-214 can recognize caspase-1 and inhibit cell proliferation and migration through the regulation of pyroptosis intermediated by caspase one in glioma cells (U87 and T98G) (Jiang Z et al., 2017), and another study showed that CAR T cell can release GZMB and then process pro-caspase-3 into mature caspase-3 in target cells to cleave GSDME, producing the N-terminal fragment of GSDME, which promotes Finalymembrane pore formation to induce pyroptosis (Liu Y et al., 2020). The gene discussed is GSDME; the disease is central nervous system cancer.