Necroptosis can be initiated in response to cellular stress, cellular damage, or infection through several means, including binding to extrinsic apoptotic death receptors, i.e., Toll-like receptors (TLRs) by TIR-domain-containing adapter-inducing interferon-β (TRIF), and in response to viral infections through Z-DNA-Binding Protein 1 (ZBP1) (Koren and Fuchs, 2021). Here, ZBP1 is linked to infection.