CD274 and cancer: Overall, the following mechanisms might be at play: anti-PD-L1 mAb can strengthen activated CD8 T cells killing cancer cells in ferroptosis via the IFN-γ-JAK1-STAT1 signaling pathway; DAMPs released by ferroptotic cells help in DCs maturation, which induces CD8 T cell activation; activated CD8 T cells then mediate cancer cells apoptosis, inhibiting ferroptosis through binding of TYRO3 and Pros1 or Gas6.