In a prophylactic tumor vaccination model, necroptotic cancer cells showed CD8+ T cell cross-priming, protection against challenge with live tumor cells, and a TA-specific IFN-γ response; in addition, DAMPs released from the necroptotic cancer cells activated DC maturation in co-culture, strongly indicating the immunogenic nature of necroptosis (Krysko et al., 2017). This evidence concerns the gene CD8A and cancer.