Compared with h3T cells, h3T-p53 knockout T cells exhibited enhanced glycolytic ability that correlated with increased proliferation, cytolytic capacity, IFN-γ secretion, expression of stemness gene signature, and decreased TGF-β signaling, and subsequently such T cells could control murine melanoma more effectively (Banerjee et al., 2016). The gene discussed is IFNG; the disease is melanoma.