In chronic lymphoid leukemia, upregulated levels of CD19 and CD37 have been observed; in AML patients, EVs rich in myeloblastic markers like CD34, CD33, and CD117 have been seen; while multiple myeloma patients have been screened based on EVs with CD38, CD138, CD44 and CD147 markers (Szczepanski et al., 2011; Harshman et al., 2016; Razmkhah et al., 2017). The gene discussed is CD44; the disease is lymphoid leukemia.