Despite this discrepancy in lipid droplet alterations in different patient fibroblast lines, which suggests that different MFN2 variants can impact lipid droplets in distinct ways, and the fact that only a few MFN2 variants have been studied, it is not unreasonable to suggest that lipid droplet impairments may contribute to the pathology of CMT2A, as impairment of lipid droplets is linked to motor neuron and neurodegenerative diseases (Pennetta and Welte, 2018; Farmer et al., 2020). Here, MFN2 is linked to neurodegenerative disease.