RHOT1 and Parkinson disease: Parkinson disease (PD) is another neurodegenerative disorder known to involve impairments in MERCs (Basso et al., 2018; Moore and Holzbaur, 2018; Puri et al., 2019), one example being the fact that MIRO1 is a PD associated gene, with pathogenic variants showing impairments in MERCs, along with reduced mitochondrial motility and mitophagy (Berenguer-Escuder et al., 2020).