c-Abl has been reported to be activated in other lysosomal and/or neurodegenerative diseases, including NPC disease, Gaucher disease (Yanez et al., 2021), Alzheimer’s, and Parkinson’s disease (Alvarez et al., 2004; Alvarez et al., 2008; Imam et al., 2011; La Barbera et al., 2021). The gene discussed is ABL1; the disease is neurodegenerative disease.