It was worth mentioning that the expression of inflammation related genes (IFN-γ and IL-4) were remarkably upregulated in HSCs at 2 m p.i. and 3 m p.i. However, in KCs, the IFN-γ was remarkably downregulated and IL-4 still upregulated at 2 m p.i. and 3 m p.i. Additionally, the fibrosis related factors including α-SMA and Col1α1 showed a sharp increase in 3 m p.i., suggesting the persistence of inflammatory responses in the infection and the occurrence of fibrosis. The gene discussed is COL1A1; the disease is dry eye syndrome.