While in KCs, the enriched biological processes included immune system process, acute-phase response, cellular response to IFN-β and exogenous drug catabolic process (Supplementary Figures S5 A, B, Supplementary Table S6), and the enriched pathways included complement and coagulation cascades, TNF signaling pathway, cytokine-cytokine receptor interaction, IL-17 signaling pathway and PPAR signaling pathway (Supplementary Figures S5C,D, Supplementary Table S5). This evidence concerns the gene TNF and dry eye syndrome.