TMB appears to have a considerable impact on the prognosis of STAD, in a study that included TGCA data from 375 gastric cancer patients, 15.7% of the patients had high TMB, and screening 632 up-regulated genes and 979 down-regulated genes were selected (Bai et al., 2020), further pathway analysis showed that patients in the high TMB group were associated with high activated CD4+ memory T cells, follicular helper T cells, quiescent NK cells, M0 and M1 macrophages, and neutrophils Cell infiltration. Here, CD4 is linked to gastric adenocarcinoma.