Some gene mutations, such as in the enzyme ribonuclease L (innate immune defense mechanisms against a viral infection), ELAC2 Zinc phosphodiesterase (endonuclease possibly involved in mitochondrial tRNA maturation), macrophage scavenger receptor 1 (endocytosis of modified low-density lipoproteins), BRAC1/BRAC2 and in chromosome X (since it contains the gene of androgen receptors), have been reported to transfer down through generations and enhance the probability of PCa development (Rawla, 2016). The gene discussed is RNASEL; the disease is posterior cortical atrophy.