Furthermore, they are responsible for an increase in insulin production, which promotes tumor aggressiveness by activating the PI3K/AKT/mTOR pathway, allowing tumor mass to progress (Avgerinos et al., 2019); 2) the overproduction of sexual hormones, due to the biggest proportion of peripheral adipose tissue, causes pathway alterations that increase the likelihood of cancer development. This evidence concerns the gene AKT1 and neoplasm.