IGF1 and posterior cortical atrophy: In CRPC, other molecular pathways are activated to fulfill the needs of PCa cells and allow them to proliferate and grow, including growth factor-β (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF) and insulin-like growth factor (IGF), all establishing a connection nominated as “cross-talk” (Bott and Ng, 2015).