Prostate cancer antigen 3 (PCA3) is another overexpressed gene in PCa that can be used as a biomarker alongside PSA values, being detected in urine with a cut-off of 35; a combination of TMPRSS2-ERG/PCA3/serum PSA detection was reported to have a specificity and sensitivity of 90 and 80%, respectively (Litwin and Tan, 2017; Sivaraman and Bhat, 2017). Here, KLK3 is linked to posterior cortical atrophy.