CYP17A1 and posterior cortical atrophy: Once single nucleotide polymorphisms in the genes of hydroxysteroid, dehydrogenase-1, hydroxy-delta-5-steroid dehydrogenase, 5α-reductase-1 and -2, testosterone, dihydrotestosterone, estrogen receptors, CYP17, CYP3A4, and CYP19A1 were linked to the androgen signaling pathway, it was thought to be one of the most important pathways regulating PCa (Rawla, 2016).