Activated by testosterone and dihydrotestosterone (DHT) which leads to differentiation, proliferation and apoptosis of epithelial prostate cells (Bott and Ng, 2015), AR is particularly crucial in PCa, to the point where blocking them is one of the most popular therapeutic approaches in cases where surgical removal is unfeasible or when it has metastatic. The gene discussed is AR; the disease is posterior cortical atrophy.