Furthermore, they are responsible for an increase in insulin production, which promotes tumor aggressiveness by activating the PI3K/AKT/mTOR pathway, allowing tumor mass to progress (Avgerinos et al., 2019); 2) the overproduction of sexual hormones, due to the biggest proportion of peripheral adipose tissue, causes pathway alterations that increase the likelihood of cancer development. The gene discussed is INS; the disease is cancer.