AR activation caused by hyperglycemia activates the AMPK pathway, resulting in glycolysis and lipogenesis activation; it also plays a role in HER/neu pathway activation, which increases aggressiveness and leads to a poor prognosis in PCa; however, an increase in GLUT1 expression was also observed in PCa, which may reduce hyperglycemia state (Antunes et al., 2018). This evidence concerns the gene SLC2A1 and Hyperglycemia.