NKX3-1 and posterior cortical atrophy: Prostate Specific Antigen (PSA) detection is a screening process that uncovers PSA, which is produced by the normal prostate but overexpressed in PCa due to the NKX3.1 mutation, and when levels are greater than 4 ng/ml, a PCa prognosis is established (Sivaraman and Bhat, 2017).