When administered in combination therapy with the HDAC inhibitor SAHA, JQ1 induces expression of the P57 (CDKN1C) tumor suppressor in mouse pancreatic ductal adenocarcinoma, which correlates with increased acetylation of histone H3 tails at the P57 promoter (Mazur et al., 2015). The gene discussed is CDKN1C; the disease is pancreatic ductal adenocarcinoma.