MTOR and prostate cancer: Similarly, curcumin also affects multiple other proteins and pathways, such as c-Jun/activator protein 1 (AP-1), cyclin D1, CDK-4, phosphatidylinositol 3-kinase (PI3K)/mechanistic target of rapamycin (mTOR)/E-twenty six proto-oncogene 2 (ETS2) pathway to reduce proliferation, cell growth in androgen-sensitive prostate cancer cell lines [77-79].