An interesting study by Jeeyun Lee et al. investigated if interferon (IFN)-α stimulation activates an NF-κB in lung cancer cells, and if curcumin annuls IFN-α dependent NF-κB activation and subsequently NF-κB-regulated gene's (cyclooxygenase-2's) expression [49]. The gene discussed is NFKB1; the disease is lung carcinoma.