Most mutations that have been linked to CPVT are found in two genes, i.e., ryanodine receptor 2 (RyR2) and calsequestrin 2 (CASQ2), two proteins fundamentally involved in the regulation of intracellular Ca2+ in cardiac myocytes (Priori et al., 2002; Faggioni and Knollmann, 2012). This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.