RYR2 and catecholaminergic polymorphic ventricular tachycardia: Analysis of local Ca2+ release events in iPSC-CM loaded with the Ca2+ indicator Fluo-4 showed that CPVT cardiomyocytes bearing a mutation in a proposed calstabin binding site (RyR2-F2483I, not conserved in unc-68) exhibit higher amplitudes and longer durations of spontaneous local Ca2+ release events already at a basal state (Fatima et al., 2011).