We inserted six CPVT-causing mutations via clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 into unc-68 and csq-1, the Caenorhabditis elegans homologs of RyR and CASQ, respectively. The gene discussed is RYR1; the disease is catecholaminergic polymorphic ventricular tachycardia.