CASQ1 and Arrhythmia: After working with extrachromosomal arrays in a previous study (Fischer et al., 2017), we now inserted six different CPVT mutations into C. elegans unc-68 or csq-1 (Table 1) via different CRISPR-Cas9 approaches (Ward, 2015; Prior et al., 2017) and introduced them into our optogenetic arrhythmia model, a C. elegans strain expressing ChR2 in PMCs (Schuler et al., 2015; Fischer et al., 2017).