IL10 and obesity due to melanocortin 4 receptor deficiency: In view of this, some remaining questions were as follows: “Is it necessary to have five MICT sessions per week?” “If we associate training in fewer weekly sessions with a dietary intervention, could it lead to the same adaptations?” “Would the magnitude be the same?” Thus, the aim of this study was to investigate the effects of three MICT weekly sessions, dietary intervention, or both interventions combined, on the modulation of the inflammatory profile (IL-6, TNF-α, and IL-10) of skeletal muscle and VAT in rats with diet-induced obesity.