Moreover, in vivo, KIF4A overexpression in MB49 cell decrease the proliferation levels of CD8+ T cells in subcutaneous tumors and treatment with a CXCL5-neutralizing antibody significantly recovered the proliferation levels of CD8+ T cell in MB49-KIF4A tumor-bearing mice (Fig. 6I,J). This evidence concerns the gene CXCL5 and neoplasm.