Accordingly, MaR1 supplementation in DSS-colitis rats increased the expressions of different tight junction proteins (ZO-1, OCLN), while inhibited the mucosal damage, colon shortening, inflammatory cell infiltration, and expressions of different pro-inflammatory mediators (PGE2, MPO, ROS, TNF-α, IL-1β/-6) [72]. Here, MPO is linked to colitis.