Therefore, inhibition of CE generation may disrupt intracellular cholesterol homeostasis and consequently inactivate Sterol Regulatory Element-Binding Protein 1 (SREBP1) leading to downregulation of SREBP1 regulated processes such as caveolin-1/MAPK activation, reduced LDLr expression and reduced LDLr mediated uptake of essential fatty acids, such as arachidonic acid (a proliferation factor in many cancers) [16, 17, 44]. This evidence concerns the gene LDLR and cancer.