The main feature of VHL is that it is a critical regulator of the ubiquitous oxygen-sensing pathway and can act as a substrate recognition component of an E3 ubiquitin ligase complex [13], also promote the degradation of epidermal growth factor receptor, pro-angiogenesis factors, remodeling of the extracellular matrix, and helps in apoptosis resulting tumor suppression [14]. Here, VHL is linked to neoplasm.