RISK6 is a six‐gene (GBP2, FCGR1B, SERPING1, TUBGCP6, TRMT2A, and SDR39U1) whole blood transcriptomic signature that predicts incident TB in M.tb‐infected individuals up to 12 months prior to TB diagnosis and demonstrated promising diagnostic performance for active TB [9, 10]. The gene discussed is SERPING1; the disease is tuberculosis.