RISK6 is a six‐gene (GBP2, FCGR1B, SERPING1, TUBGCP6, TRMT2A, and SDR39U1) whole blood transcriptomic signature that predicts incident TB in M.tb‐infected individuals up to 12 months prior to TB diagnosis and demonstrated promising diagnostic performance for active TB [9, 10]. This evidence concerns the gene TRMT2A and tuberculosis.