LYVE1 and lymphedema: On the other hand, LYVE1 and podoplanin are both markers of lymphatic endothelial integrity predominantly expressed in lymphatic vessels.41, 42, 43 LYVE1 and podoplanin are essential for lymphatic system development and ablation of podoplanin and LYVE1 in transgenic mice resulted in diminished lymphatic transport and lymphedema.44