In many cases, intrinsically disordered proteins (IDPs) are responsible for the formation of these protein inclusions, aggregates, and fibrils, specifically tau, α-synuclein, and Tar DNA-binding protein 43 (TDP-43), which are found in neuropathological inclusions in neurons of AD, PD, and ALS patients, respectively (5). The gene discussed is TARDBP; the disease is Alzheimer disease.