In breast cancer, lncRNA ANRIL induces gene silencing at the INK4b-ARF-INK4a locus by interacting with CBX7 (PRC1 component) and SUZ12 (PRC2 component) and regulates its adjacent tumor suppressor CDKN2A/B through epigenetic mechanisms, thereby controlling cell proliferation and senility [32]. This evidence concerns the gene CDKN2A and breast carcinoma.