High levels of Mcl-1 inhibit mitochondrial apoptosis profoundly, and this may therefore be an explanation for the broad apoptosis-inhibition by Ctr. Secondly, a loss of the pro-apoptotic Bcl-2-family member, the BH3-only protein Bim and other BH3-only proteins has been reported upon chlamydial infection [22, 26], although some of this may be an extraction artefact [27]. This evidence concerns the gene BCL2 and chlamydia trachomatis infectious disease.