IN insulin reduced appetite (F(1,50) = 5.66, p = 0.02, ηp2 = 0.10) and this effect was more pronounced for women with obesity (t(16) =−2.11, p = 0.051, d = 0.60) than for lean women (t(34) =−0.74, p = 0.47, d = 0.11). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.