APP and Alzheimer disease: We previously found that SV rescued memory in adult transgenic AD mice that overexpress a mutated form of the human amyloid precursor protein (APP mice) together with normalized or upregulated protein levels of learning- and memory-related immediate early genes c-Fos or Egr-1 in hippocampal CA1 neurons, with no effect on Aβ load, synaptic proteins or NMDA receptor subunits [15].