Our results show that (1) SV-treated APP mice recover memory concurrently with activation of the Wnt/β-catenin pathway and improved maturation and dendritic extension of DG granule cells, (2) selective blockade of Wnt/ β-catenin signaling counters SV benefits, and (3) SV’s memory benefits were replicated by selectively activating the Wnt/β-catenin pathway via inhibition of DKK1, an endogenous inhibitor of the Wnt/β-catenin pathway upregulated in brain tissue of both APP mice [32] and AD patients [31]. Here, APP is linked to Alzheimer disease.