The level of phosphorylated ATF1 at Thr184 (p-ATF1-T184) was screened using immunohistochemical analysis in a panel of tumors, including a multi-cancer tissue microarray which included 6 types of digestive system tumors (10 samples per tumor type), a tissue microarray consisting of 36 pairs of nasopharyngeal carcinoma samples and their adjacent non-tumor tissues, and histological tissue sections of glioma. The gene discussed is ATF1; the disease is central nervous system cancer.