CXCR4 and neoplasm: Finally, the Univariate Hazard Cox regression analysis showed a trend that impact of CXCR4 tumor expression (HR 0.49; 95CI 0.25 - 0.93; p = 0.031), the presence of residual disease >2cm (HR 3.67; 95CI 1.62 - 8.31; p = 0.002) as well as the number of chemotherapy cycles (HR 1.28; 95CI 1.05 - 1.55; p = 0.013) on RFS (Table 5).