In this study, through the identification of DEGs and WGCNA, we constructed a protein–protein network to determine the top 10 genes in the different modules by calculating the degree in Cytoscape, which identified three hub genes (TGFBR3, COLEC10, and FYN) that are intimately related to the survival outcome of HCC patients. This evidence concerns the gene FYN and hepatocellular carcinoma.