The lowest CD4 + T cell count measured prior to receiving live vaccination for patients with combined and syndromic immunodeficiencies were 0.910 and 0.610 × 109/L, respectively, while the lowest CD8 + T cell counts was 0.341 and 0.210 × 109/L respectively (Additional file 1: Table S5). The gene discussed is CD4; the disease is Immunodeficiency.