When comparing the ORR and DCR with nivolumab according to each potential biomarker to their counterparts, a low baseline blood NLR, normal baseline serum Na, and tumor PD-L1 CPS (≥ 1%) were associated with a higher ORR and DCR, whereas tumor EBV infection and a high TMB in the tumor were not. This evidence concerns the gene CD274 and Epstein-Barr virus infection.