In the 36 patients where tissue was available for analysis (Table 2), baseline blood NLR (≤ 2.9 vs. > 2.9) (HR 0.46, 95% CI 0.22–0.95, P = 0.037) and tumor PD-L1 CPS (≥ 1% vs. < 1%) (HR 0.32, 95% CI 0.14–0.72, P = 0.006) remained as significant factors after multivariate analysis for PFS. The gene discussed is CD274; the disease is neoplasm.