CD274 and neoplasm: Given the advantages of available tissues, consistent management, well-controlled data quality by continuous involvement of investigators throughout the study as a single institution study and an optimal two-armed design by including a control group for evaluating the predictive values, this study aimed to investigate the predictive values of potential biomarkers such as tumor PD-L1 expression, tumor MSI status, tumor EBV infection, TMB, blood NLR, and serum Na to provide objective guidance in identifying patients with clinical benefits to nivolumab.