Similarly, in the post-hoc analysis of the KEYNOTE-061 phase III study, pembrolizumab significantly improved OS compared with paclitaxel as 2nd-line therapy in patients with PD-L1 positive (CPS ≥ 10%) advanced gastric cancer, whereas PFS and OS curves between pembrolizumab and paclitaxel groups crossed in patients with PD-L1 positive (CPS ≥ 1%) gastric cancer [19]. Here, CD274 is linked to gastric cancer.