In patients with tumor PD-L1 CPS (< 1%), the median PFS was 1.4 months in the nivolumab group and 2.6 months in the placebo group (P = 0.897), and the median OS was 5.9 months in the nivolumab group and 5.5 months in the placebo group (P = 0.681) (Fig. 2) (Pfor interaction = 0.003). Here, CD274 is linked to neoplasm.