MNDA down-regulation in CAC + PCR might reflect down-regulation of INFα, a powerful antiviral factor, in an attempt of SARS-CoV-2 to endorse its own propagation and infectability (Gu et al. 2022). The application of IFNα therapy to COVID-19 patients resulted in accelerated viral clearance from the upper airways and in a reduction of the inflammatory biomarkers IL-6 and C-reactive protein (CRP) (Zhou et al. 2020). The gene discussed is CRP; the disease is COVID-19.